Assistant Professor of Pediatrics Ryan Gray, PhD, will speak on "Towards a Mechanistic Understanding of Spine Defects: The Role of Gpr126 in the Intervertebral Disc." The talk is part of the Institute for Cellular and Molecular Biology Seminar Series hosted by David Stein, PhD.
Adolescent idiopathic scoliosis (AIS) and pectus excavatum (PE) are common pediatric musculoskeletal disorders. Little is known about the tissue of origin for either condition, or about their genetic bases. Common variants near GPR126 (encoding the adhesion G protein-coupled receptor 126), were recently shown to be associated with AIS in humans. We provide genetic evidence that loss of Gpr126 in osteochondroprogenitor cells alters cartilage biology and spinal column development.